Malate Dehydrogenase is a simple redox reaction recognizable to students from the tricarboxylic acid cycle. However, MDH plays a much more complicated role in a range of metabolic pathways supporting cellular function in a variety of states and organisms. This diversity of metabolic roles and the regulation of its function make MDH a nearly endless source of interesting untapped research projects. This is page contains the basics of MDH structure function and published works.
General Background (Faculty Only: Password Required: contact Ellis Bell, jbell@sandiego.edu to register for a password to access this material)
You will find the following sections:
- A Brief Introduction to Malate Dehydrogenase
- Introduction to the Role of the Active Site Loop Region of watermelon glyoxysomal MDH
- Allosteric Regulation and Malate Dehydrogenases
- Mammalian MDH Metabolism, Disease
Mammalian MDH Expression, Structure & Kinetics.
- Mammalian MDH Structure, Mechanism and Kinetics
- Mammalian MDH and Hydroxyglutarate Metabolism
- MDH Post Translational Modification: Phosphorylation, Methylation and Acetylation
- MDH Protein-Protein Interactions